Patricia Kulka

Astrocyte fatty acid uptake and ketogenesis in the mediobasal hypothalamus coordinate adaptive metabolic responses against high-fat diet exposure in male rodents

This study shows that MBH astrocyte lipid metabolism, specifically fatty acid uptake and ketogenesis, plays a key role in regulating energy balance and mitigating high-fat diet-induced obesity in male rodents.

Depletion of astrocyte inflammatory pathway in the arcuate nucleus of the hypothalamus is sufficient to prevent the diet-induced metabolic alterations of polygenically predisposed obese rats

This study shows that reducing astrocyte inflammation in the hypothalamus prevents obesity in genetically predisposed rats but not once obesity has developed.