The biodistribution and effect of post-exposure neutralising monoclonal antibody treatment in a mouse model of SARS-CoV-2 infection with viral spread to the brain
Janine Schlaepfer, Simon De Neck, Rebekah Penrice-Randal, Parul Sharma, Adam Kirby, Lee M. Tatham, Eduardo Gallardo Toledo, Joanne Herriott, Edyta Kijak, Joanne Sharp, James P. Stewart, Andrew Owen, Anja Kipar
This study investigates the biodistribution and effects of Ronapreve in a mouse model of SARS-CoV-2 infection, showing it does not reach the brain but reduces viral loads in the lung and brain.
bioRxiv · May 29, 2026 · PreprintPathology