Christelle Le Foll

Astrocyte fatty acid uptake and ketogenesis in the mediobasal hypothalamus coordinate adaptive metabolic responses against high-fat diet exposure in male rodents

This study shows that MBH astrocyte lipid metabolism, specifically fatty acid uptake and ketogenesis, plays a key role in regulating energy balance and mitigating high-fat diet-induced obesity in male rodents.

The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot

This study identifies a rostral hotspot in the medial nucleus accumbens shell regulated by D1-SPNs that controls hedonic feeding, introducing Stard5 as a molecular marker for targeted manipulation.

Depletion of astrocyte inflammatory pathway in the arcuate nucleus of the hypothalamus is sufficient to prevent the diet-induced metabolic alterations of polygenically predisposed obese rats

This study shows that reducing astrocyte inflammation in the hypothalamus prevents obesity in genetically predisposed rats but not once obesity has developed.

Sensory neurons shape macrophage identity via TGF-β signalling

This study identifies TGF-β as a key mediator of macrophage specialization in the skin through interaction with sensory nerves.

A Cross-Species Atlas of the Dorsal Vagal Complex Reveals Neural Mediators of Cagrilintide's Effects on Energy Balance

The paper creates a cross-species atlas of the dorsal vagal complex using single-nucleus RNA sequencing and spatial profiling, revealing molecular mechanisms of cagrilintide's effects on energy balance.