Rare genetic variation in Fibronectin 1 (FN1) protects against APOEe4 in Alzheimer's disease
Prabesh Bhattarai, Tamil Iniyan Gunasekaran, Michaël E. Belloy, Dolly Reyes‐Dumeyer, Dörthe Jülich, Hüseyin Tayran, Elanur Yılmaz, Delaney Flaherty, Bengisu Turgutalp, Gauthaman Sukumar, Camille Alba, Elisa Martinez McGrath, Daniel N. Hupalo, Dagmar Bačíková, Yann Le Guen, , Badri Narayan Vardarajan
The paper identifies rare FN1 variants that protect APOEε4 carriers from Alzheimer's disease by modulating extracellular matrix deposition and gliosis.
Acta Neuropathologica · Apr 10, 2024Peer-reviewedGenetics