Author

Sharanya Sivakumar

Columbia University Irving Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Assay:DNA methylation· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Andrew F. TeichiD· 4 shared Badri Narayan VardarajaniD· 3 shared Benjamin Ciener· 3 shared Sandra LeskineniD· 3 shared Annie LeeiD· 2 shared Annie OF HinikeriD· 2 shared Brittany N. DuggeriD· 2 shared David Alan BennettiD· 2 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersNeuroscience

Andrew F. TeichORCID

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Author profile →

4 papers

Recent·Most cited

An analysis of RNA quality metrics in human brain tissue

Jiahe Tian, Tiffany G. Lam, Sophie K. Ross, Benjamin Ciener, Sandra Leskinen, Sharanya Sivakumar, David A. Bennett, Vilas Menon, Guy M. McKhann, Alexi M. Runnels, Andrew F. Teich

The paper evaluates how pre-sequencing RNA quality metrics (PMI and RIN) correlate with post-sequencing RNA quality metrics and gene expression in human brain tissue.

Journal of Neuropathology & Experimental Neurology · Dec 9, 2024Peer-reviewedNeuroscience

MU-BRAIN: MUltiethnic Brain Rna-seq for Alzheimer INitiative

Zikun Yang, Basilio Cieza, Dolly Reyes‐Dumeyer, Annie Lee, Yiyi Ma, Elanur Yılmaz, Rafael Lantigua, Gary Wright Miller, Lewis M. Brown, Lawrence S. Honig, Benjamin Ciener, Sandra Leskinen, Sharanya Sivakumar, Badri Narayan Vardarajan, Brittany N. Dugger, , Giuseppe Tosto

The paper analyzes bulk RNA-seq data from diverse ethnic groups to identify differentially expressed genes and pathways in Alzheimer's Disease, highlighting cross-ethnic and ethnic-specific findings.

bioRxiv · Feb 20, 2024 · PreprintGenetics

Multi-omics Characterization of Epigenetic and Genetic Risk of Alzheimer Disease in Autopsied Brains from two Ethnic Groups

Yiyi Ma, Dolly Reyes‐Dumeyer, Angel L. Piriz, Patricia Recio, Diones Rivera Mejía, Martin A. Medrano, Rafael Lantigua, Jean Paul Vonsattel, Giuseppe Tosto, Andrew F. Teich, Benjamin Ciener, Sandra Leskinen, Sharanya Sivakumar, Michael A. Deture, Duara Ranjan, , Badri Narayan Vardarajan

The paper identifies six genetic loci associated with Alzheimer's disease in Hispanics, showing both genetic and epigenetic risks, with some downstream effects on mRNA expression being ethnicity-specific.

medRxiv · Feb 12, 2024 · PreprintGenetic & Genomic Medicine

ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer's disease

Anne Marie W. Bartosch, Elliot H. H. Youth, Shania Hansen, Yiyang Wu, Heather M. Buchanan, Maria E. Kaufman, Harrison Xiao, So Yeon Koo, Archana Ashok, Sharanya Sivakumar, Rajesh Kumar Soni, Logan C. Dumitrescu, Tiffany G. Lam, Ali S. Ropri, Annie Lee, , Andrew F. Teich

This study shows ZCCHC17 regulates RNA splicing in neurons and its dysfunction contributes to splicing abnormalities in Alzheimer's disease, with potential therapeutic implications.

Journal of Neuroscience · Nov 22, 2023Peer-reviewedNeuroscience