Author

Patrick Mark Downey

UCB Pharma (Belgium)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Anass ChikiiD· 2 shared Anne MicheliD· 2 shared Anne‐Laure Mahul‐MellieriD· 2 shared Caroline HaikaliD· 2 shared Catherine Strand· 2 shared Georges Mairet‐Coello· 2 shared Graham William KnottiD· 2 shared Hilal Ahmed LashueliD· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintNov 29, 2024

Dissecting the differential role of C-terminal truncations in the regulation of aSyn pathology formation and the biogenesis of Lewy bodies

Anne‐Laure Mahul‐Mellier, Melek Firat Altay, Niran Maharjan…·Hilal Ahmed Lashuel

This study investigates how C-terminal truncations of alpha-synuclein (aSyn) affect Lewy body (LB) formation and pathology in Parkinson's disease by analyzing their role in fibril processing and aggregation.

4 citations

experimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintJun 27, 2023

Two-color coincidence single-molecule pull-down for the specific detection of disease-associated protein aggregates

Rebecca S. Saleeb, Craig Leighton, Jieun Lee…·Mathew H. Horrocks

This paper introduces a method to specifically detect disease-associated protein aggregates using two-color coincidence single-molecule pull-down, demonstrating its effectiveness with alpha-synuclein in human biofluids.

DOI 10.1101/2023.06.27.546642

humanproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 19, 2018

The making of a Lewy body: the role of alpha-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions.

Anne‐Laure Mahul‐Mellier, Melek Firat Altay, Johannes Burtscher…·Hilal Ahmed Lashuel

Calpain-1/2 cleavage of the alpha-synuclein C-terminus after fibril formation is reported to drive seeding, aggregation and the maturation of Lewy-body-like inclusions in primary neurons.

45 citations

humanexperimental assay

𝕏 PostBluesky