Author

Anne Michel

UCB Pharma (Belgium)ORCID 0000-0002-7271-7903Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1

Frequent Co-Authors

Anass ChikiiD· 2 shared Anne‐Laure Mahul‐MellieriD· 2 shared Caroline HaikaliD· 2 shared Catherine Strand· 2 shared Georges Mairet‐Coello· 2 shared Graham William KnottiD· 2 shared Hilal Ahmed LashueliD· 2 shared Janice L. HoltoniD· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Anass ChikiORCID

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2 papers

Recent·Most cited

Dissecting the differential role of C-terminal truncations in the regulation of aSyn pathology formation and the biogenesis of Lewy bodies

Anne‐Laure Mahul‐Mellier, Melek Firat Altay, Niran Maharjan, Nadine Ait‐Bouziad, Anass Chiki, Somanath Jagannath, Galina Limorenko, Salvatore Novello, Jonathan Ricci, Siv Vingill, Richard Wade‐Martins, Janice L. Holton, Catherine Strand, Caroline Haikal, Jiayi Li, , Hilal Ahmed Lashuel

This study investigates how C-terminal truncations of alpha-synuclein (aSyn) affect Lewy body (LB) formation and pathology in Parkinson's disease by analyzing their role in fibril processing and aggregation.

bioRxiv · Nov 29, 2024 · PreprintNeuroscience

The making of a Lewy body: the role of alpha-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions.

Anne‐Laure Mahul‐Mellier, Melek Firat Altay, Johannes Burtscher, Niran Maharjan, Nadine Ait‐Bouziad, Anass Chiki, Siv Vingill, Richard Wade‐Martins, Janice L. Holton, Catherine Strand, Caroline Haikal, Jiayi Li, Romain Hamelin, Marie Croisier, Graham William Knott, , Hilal Ahmed Lashuel

Calpain-1/2 cleavage of the alpha-synuclein C-terminus after fibril formation is reported to drive seeding, aggregation and the maturation of Lewy-body-like inclusions in primary neurons.

bioRxiv · Dec 19, 2018 · PreprintNeuroscience