HIPK2 regulates homology-directed DNA repair and PARP inhibitor sensitivity
Patrick Weyerhäuser, Pierre‐Olivier Frappart, Georg Nagel, Stephan Krieg, Teodora Nikolova, Wynand Paul Roos, Kaveri Raja, Sahar Karbassi, Steffen Dickopf, Magdalena C. Liebl, Daniela Pfeiffer, Huong Becker, Yang He, Markus Christmann, Matthias Altmeyer, Thomas G. Hofmann
This study identifies HIPK2's role in HR repair and PARPi sensitivity by regulating BRCA1 stability, suggesting HIPK2 inhibition as a therapeutic strategy for BRCA1-proficient cancers.
bioRxiv · Jun 1, 2026 · PreprintCell Biology