Matthias Altmeyer

This study shows that excess cell size drives senescence by altering mRNA homeostasis and reorganizing the genome, leading to the secretory phenotype and cell cycle arrest.

This study identifies HIPK2's role in HR repair and PARPi sensitivity by regulating BRCA1 stability, suggesting HIPK2 inhibition as a therapeutic strategy for BRCA1-proficient cancers.

This study uses time-resolved single-molecule FRET to show that PAR length determines nucleosome decompaction efficiency and reversibility.

The paper investigates a BRCA2 truncating variant's effect on NF-κB-driven transcription by showing it disrupts the BRCA2-PCAF complex, reducing histone acetylation and impairing cell migration.

This study shows the NSL complex prevents R-loop induced replication stress during neural development, leading to developmental abnormalities when disrupted.

This study identifies FANCL and Ube2T as HR-promoting factors at DSBs and shows they regulate CtIP recruitment and end-resection for homologous recombination.

This study investigates the roles of MBD2 and MBD3 isoforms in NuRD complex function during differentiation, showing that MBD2b can fully rescue MBD3 loss while MBD2t cannot.