Astrocytic PIEZO activation by heartbeat sound promotes extracellular matrix and maturation in human brain organoids
Alexandra Ferreira-Oliveira, Florian Rambow, Samira Rambow-Makhzami, Yury A. Nikolaev, Angelo Novak, Olga Shevchuk, Hannah Voß, Daniel Robert Engel, Paul A Schult, Matthias Pillath‐Eilers, Britta Kaltwasser, Ulf Brockmeier, Christoph Kleinschnitz, Dirk Matthias Hermann, Egor Dzyubenko
This study shows that heartbeat sound activates PIEZO channels in astrocytes, promoting extracellular matrix synthesis and neural differentiation in human brain organoids.
bioRxiv · Oct 21, 2025 · PreprintNeuroscience