Author

Paulina M. Naydenkov

California Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Achraf NoureddineiD· 1 shared Aliia R. FatkhullinaiD· 1 shared Asha J. BozicevichiD· 1 shared Benjamin R MarwedeliD· 1 shared Braden JuengeliD· 1 shared C.Y. DangiD· 1 shared Carmine Schiavone· 1 shared Daria EsterházyiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperImmunology

Achraf NoureddineORCID

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3 papers

Recent·Most cited

Model-guided design of single-cargo, dual-attractor gene circuits

Emma L. Peterman, Nick Nolan, Paulina M. Naydenkov, Diya R. Godavarti, Domitilla Del Vecchio, Kate E. Galloway

This paper designs single-cargo synthetic gene circuits that generate two balanced cellular states without relying on copy-number variation.

bioRxiv · Oct 20, 2026 · PreprintSynthetic Biology

Rational Design of Immunogenic Nanoparticles as a Platform for Enhanced Ovarian Cancer Immunotherapy in Mice

Lien Tang, Benjamin R Marwedel, C.Y. Dang, Marian Olewine, Melanie S. Jun, Paulina M. Naydenkov, Lorél Y. Medina, Veronica Gayoso, Ngoc Doan, Shamus L O'Leary, Carmine Schiavone, Joseph Cave, Tamara A. Howard, John D. Watt, Prashant Dogra, , Achraf Noureddine

This paper designs immunogenic nanoparticles to enhance ovarian cancer immunotherapy in mice by co-loading multiple therapeutic agents and adjuvants, showing improved survival and immune activation.

bioRxiv · Jun 5, 2025 · PreprintImmunology

Inducible, but not constitutive, pancreatic REG/Reg isoforms are regulated by intestinal microbiota and pancreatic diseases

Yixuan Zhou, Macy R. Komnick, Fabiola Sepulveda, Grace Liu, Elida Nieves-Ortiz, Kelsey Meador, Ornella Ndatabaye, Aliia R. Fatkhullina, Asha J. Bozicevich, Braden Juengel, Natalie J. Wu-Woods, Paulina M. Naydenkov, Johnathan R. Kent, Nathaniel Christiansen, Maria Lucia L. Madariaga, , Daria Esterházy

The paper investigates differences in REG/Reg isoform expression and regulation in pancreas and gut, finding inducible isoforms are regulated by microbiota and pancreatic diseases.

Mucosal Immunology · May 19, 2025Peer-reviewedImmunology