Author

Maria Lucia L. Madariaga

University of ChicagoORCID 0000-0002-2950-7230Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Johnathan R. KentiD· 3 shared Nathaniel Christiansen· 2 shared Alexander MuiriD· 1 shared Aliia R. FatkhullinaiD· 1 shared Amir Sadek· 1 shared Amy DeikiD· 1 shared Anna Shevzov-Zebrun· 1 shared Asha J. BozicevichiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

Johnathan R. KentORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Intraoperative arteriovenous patient sampling to assess in situ non-small cell lung cancer metabolism

Johnathan R. Kent, Keene L. Abbott, Rachel K. Nordgren, Amy Deik, Nupur Kanti Das, Millenia Waite, Tenzin Kunchok, Anna Shevzov-Zebrun, Nathaniel Christiansen, Amir Sadek, Darren S. Bryan, Mark K. Ferguson, Jessica Scott Donington, Alexander Muir, Yatrik Madhukar Shah, , Peggy P. Hsu

This study uses intraoperative arteriovenous sampling to measure tumor metabolism in NSCLC patients, revealing distinct metabolic profiles between tumor and normal lung tissue.

Journal of Clinical Investigation · Jan 27, 2026Peer-reviewedCancer Biology

Inducible, but not constitutive, pancreatic REG/Reg isoforms are regulated by intestinal microbiota and pancreatic diseases

Yixuan Zhou, Macy R. Komnick, Fabiola Sepulveda, Grace Liu, Elida Nieves-Ortiz, Kelsey Meador, Ornella Ndatabaye, Aliia R. Fatkhullina, Asha J. Bozicevich, Braden Juengel, Natalie J. Wu-Woods, Paulina M. Naydenkov, Johnathan R. Kent, Nathaniel Christiansen, Maria Lucia L. Madariaga, , Daria Esterházy

The paper investigates differences in REG/Reg isoform expression and regulation in pancreas and gut, finding inducible isoforms are regulated by microbiota and pancreatic diseases.

Mucosal Immunology · May 19, 2025Peer-reviewedImmunology

Mutability and hypermutation antagonize immunoglobulin codon optimality

Joshua J.C. McGrath, Juyeon Park, Chloe A. Troxell, Jordan C. Chervin, Lei Li, Johnathan R. Kent, Siriruk Changrob, Yanbin Fu, Min Huang, Nai‐Ying Zheng, G. Dewey Wilbanks, Sean A. Nelson, Jiayi Sun, Giorgio Inghirami, Maria Lucia L. Madariaga, , Patrick C. Wilson

The paper examines how immunoglobulin codon optimality interacts with mutability and hypermutation in antibody evolution, finding that codon deoptimization correlates with expression loss and is constrained by selective pressures.

Molecular Cell · Dec 20, 2024Peer-reviewedImmunology