Emma L. Peterman

This paper designs single-cargo synthetic gene circuits that generate two balanced cellular states without relying on copy-number variation.

The paper shows that gene syntax influences supercoiling-mediated transcriptional feedback, affecting adjacent gene expression in human cells.

DIAL is a framework for designing synthetic promoters that generate heritable, tunable gene expression setpoints across cell types.

The paper designs and characterizes ComMAND, a microRNA-based gene circuit that precisely controls transgene expression in diverse primary cells.

The paper measures mRNA and protein levels in single cells for synthetic promoters, finding that promoter strength affects both transcription and translation, and introduces a framework for comparing gene regulation.