The mitochondrial dicarboxylate carrier mediates in vivo hepatic gluconeogenesis
Daniel J. Pape, Kelly C. Falls-Hubert, Ronald A. Merrill, Adnan Ahmed, Qingwen Qian, Gavin R. McGivney, Paulina Sobieralski, Adam J. Rauckhorst, Ling Yang, Eric B. Taylor
This study shows that the mitochondrial dicarboxylate carrier mediates hepatic gluconeogenesis from lactate/pyruvate and contributes to glucose homeostasis in a T2D mouse model.
bioRxiv · Sep 12, 2024 · PreprintBiochemistry