Adam J. Rauckhorst

Metabolic Reprogramming Induced by Mitochondrial Citrate Carrier Deletion Mitigates Antibiotics-Induced Acute Tubular Injury

This study shows that deleting the mitochondrial citrate carrier in kidney tubules reduces antibiotic-induced acute tubular injury by altering metabolism and increasing antioxidants.

PANK2-mediated de novo CoA synthesis is required for metabolic switching to fatty acid oxidation

The paper shows PANK2 enables CoA synthesis during fatty acid oxidation by overcoming feedback inhibition, supporting its role in metabolic switching.

The mitochondrial dicarboxylate carrier mediates in vivo hepatic gluconeogenesis

This study shows that the mitochondrial dicarboxylate carrier mediates hepatic gluconeogenesis from lactate/pyruvate and contributes to glucose homeostasis in a T2D mouse model.

Mitochondrial citrate metabolism and efflux regulates trophoblast differentiation

This study shows that mitochondrial citrate metabolism and efflux regulate trophoblast differentiation through effects on histone acetylation and gene expression.