Ling Yang

Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline

This study investigates the role of BAT ADH5 in aging, showing that its loss accelerates BAT senescence and metabolic decline, while HSF1 activation mitigates these effects.

Proinflammatory cytokines mediate pancreatic beta-cell specific alterations to Golgi morphology via iNOS-dependent mitochondrial inhibition

This study shows proinflammatory cytokines alter pancreatic beta-cell Golgi structure via iNOS-dependent mitochondrial inhibition, contributing to secretory dysfunction in T1D.

The mitochondrial dicarboxylate carrier mediates in vivo hepatic gluconeogenesis

This study shows that the mitochondrial dicarboxylate carrier mediates hepatic gluconeogenesis from lactate/pyruvate and contributes to glucose homeostasis in a T2D mouse model.

Gamma-interferon-inducible lysosomal thiol reductase maintains cardiac immuno-metabolic homeostasis in heart failure

This study identifies GILT's role in maintaining cardiac immuno-metabolic homeostasis, showing its deficiency leads to heart failure in mice.

ADH5-mediated NO Bioactivity Maintains Metabolic Homeostasis in Brown Adipose Tissue

This study shows ADH5 maintains BAT metabolic homeostasis by regulating S-nitrosylation and thermogenesis under obesity and cold stress.

A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β-cells

The paper identifies a micropeptide encoded by a long noncoding RNA that regulates pancreatic β-cell function and insulin secretion.