Author

Pedro R. Lowenstein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Mahmoud S. AlghamriiD· 2 shared Maria B. Garcia-Fabiani· 2 shared Maria G. Castro· 2 shared Mats Ljungman· 2 shared Maureen A. SartoriD· 2 shared Padma Kadiyala· 2 shared Tingting QiniD· 2 shared Alan Meeker· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCancer Biology

Mahmoud S. AlghamriORCID

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2 papers

Recent·Most cited

Epigenetic reprogramming of autophagy leads to uncovering a novel therapeutic target for mutant IDH1 astrocytomas

Felipe J Núñez, Kaushik Banerjee, Anzar A. Mujeeb, Ava Mauser, Claire E. Tronrud, Ziwen Zhu, Sadhakshi Raghuram, Maya R. Sheth, Jorge Armando Pena Agudelo, Julio Zelaya, Ayman Taher, Padma Kadiyala, Stephen V. Carney, Maria B. Garcia-Fabiani, Andrea Comba, , Maria G. Castro

This study identifies autophagy as a critical survival pathway in mIDH1 gliomas and shows that inhibiting autophagy enhances radiosensitivity and tumor regression in preclinical models.

bioRxiv · Mar 8, 2024 · PreprintCancer Biology

IDH1R132H acts as a tumor suppressor in glioma via epigenetic upregulation of the DNA damage response

Felipe J. Núñez, Flor M. Mendez, Padma Kadiyala, Mahmoud S. Alghamri, Masha G. Savelieff, Carl Koschmann, Anda-Alexandra Calinescu, Neha Kamran, Rohin Patel, Stephen Carney, Marissa Z. Guo, Maria B. Garcia-Fabiani, Santiago Haase, Marta Edwards, Mats Ljungman, , Maria G. Castro

The paper shows IDH1R132H mutation in glioma improves survival and DNA repair by enhancing ATM signaling and radioresistance, which can be reversed by inhibiting ATM or CHK1/2.

bioRxiv · Aug 10, 2018 · PreprintCancer Biology