Tingting Qin

This study shows that inhibiting ATM signaling with AZD1390 improves radiation efficacy in H3K27M-altered diffuse midline glioma by enhancing DNA damage repair sensitivity.

This study examines HPV integration in HNSCC using RNA-seq data to link splicing events and expression ratios to poor clinical outcomes.

This paper develops a machine learning classifier to subtype HPV+ HNSCC tumors into IMU or KRT using bulk RNA-seq data and validates its accuracy across multiple cohorts.

This study identifies autophagy as a critical survival pathway in mIDH1 gliomas and shows that inhibiting autophagy enhances radiosensitivity and tumor regression in preclinical models.

The paper develops genome-wide enhancer-to-target gene assignments across >500 cell types and shows they outperform naive methods in gene set enrichment analysis.

Poly-Enrich improves gene set enrichment testing for genomic regions by modeling peak counts with a negative binomial model, outperforming previous methods in certain scenarios.

The paper shows IDH1R132H mutation in glioma improves survival and DNA repair by enhancing ATM signaling and radioresistance, which can be reversed by inhibiting ATM or CHK1/2.