DYRK1A Interacts with the Tuberous Sclerosis Complex and Promotes mTORC1 Activity
Pinhua Wang, Sunayana Sarkar, Menghuan Zhang, Tingting Xiao, Fenhua Kong, Zhe Zhang, Deepa Balasubramanian, Nandan Jayaram, Sayantan Datta, Ruyu He, Ping Wu, Peng Chao, Ying Zhang, Michael P. Washburn, Laurence A. Florens, , Man Mohan
This study identifies DYRK1A's role in promoting mTORC1 activity by inhibiting TSC complex activity through phosphorylation of TSC2, and shows conservation in Drosophila.
eLife · Oct 22, 2024Peer-reviewedMolecular Biology