Sayantan Datta

Dietary serine protects the retinal pigmented epithelium by blunting reactive oxygen species in dry age-related macular degeneration

This study shows that dietary serine reduces ROS accumulation and improves retinal function in AMD by restoring mitochondrial function and GSH levels through PHGDH regulation.

Retinal Pigment Epithelium Injury in Pentosan Polysulfate Exposure: Morphologic Changes, Phagocytic Deficits, and Mitochondrial Dysfunction

This study investigates the effects of pentosan polysulfate on retinal pigment epithelium cells, finding mitochondrial dysfunction and impaired phagocytosis.

DYRK1A Interacts with the Tuberous Sclerosis Complex and Promotes mTORC1 Activity

This study identifies DYRK1A's role in promoting mTORC1 activity by inhibiting TSC complex activity through phosphorylation of TSC2, and shows conservation in Drosophila.