Author

Zhiyong Yuan

Tianjin Medical UniversityORCID 0000-0002-4745-6895Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Hang Hubert YiniD· 2 shared Heng ZhangiD· 2 shared Jie HaniD· 2 shared Shuqin ZhangiD· 2 shared Zhikun LiuiD· 2 shared Bin LiuiD· 1 shared Hong CheniD· 1 shared Hongtao ZhuiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

Hang Hubert YinORCID

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2 papers

Recent·Most cited

Defense-associated reverse transcriptases synthesize DNA in a telomerase-like manner

Heng Zhang, Shuai Chen, Shuqin Zhang, Youjing Zhang, Pengyu Fu, Tongyu Mao, Yancheng Zhan, Jie Han, Zhikun Liu, Zhengda Shan, Zhiyong Yuan, Ying Yu, Hang Yin

This study characterizes the reverse transcription activity of DRT10 and reveals its unique 2:1 RT:ncRNA assembly and mechanism of cDNA synthesis.

bioRxiv · Oct 9, 2026 · PreprintBiochemistry

Architecture and mechanism of a dual-enzyme retron system in prokaryotic immunity

Xuzichao Li, Qiuqiu He, Yanan Liu, Bin Liu, Zhikun Liu, Hong Chen, Shuqin Zhang, Jie Han, Yingcan Liu, Jie Yang, Hang Hubert Yin, Zhenxi Guo, Yong Wei, Zhiyong Yuan, Hongtao Zhu, Heng Zhang

This study characterizes the Ec78 retron system, revealing its dual-enzyme effector complex and the molecular mechanism of phage clearance through cryo-EM structures and functional analysis.

Nature Communications · Dec 7, 2025Peer-reviewedBiochemistry