EPHA2 and scavenger receptor-directed trafficking enhances endosomal leakiness and antisense therapy delivery
Sergi Marco, Peter J. Walsh, Alexey S. Revenko, Peter A. Thomason, Lynn McGarry, A. Robert MacLeod, Sonam Ansel, Dina Tataran, Martin Bushell, Chiara Braconi, Jim C. Norman
This study identifies a mechanism by which antisense oligonucleotides (ASOs) enter cells via scavenger receptors and EPHA2-mediated trafficking to reach nuclear-adjacent endosomes, enhancing their effectiveness.
bioRxiv · Feb 5, 2025 · PreprintCell Biology