Jim C. Norman

Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer

This study shows that integrin conformation-dependent neutrophil slowing in pre-metastatic lungs obstructs capillaries and may contribute to immunosuppression in breast cancer.

Uridine Phosphorylase-1 supports metastasis of mammary cancer by altering immune and extracellular matrix landscapes of the lung

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.

Increased mRNA translation delays lung adenocarcinoma initiation and exposes a therapeutic vulnerability to MEK inhibitors

This study shows that increased mRNA translation delays lung adenocarcinoma initiation and creates a vulnerability to MEK inhibitors in KRAS-driven tumors.

EPHA2 and scavenger receptor-directed trafficking enhances endosomal leakiness and antisense therapy delivery

This study identifies a mechanism by which antisense oligonucleotides (ASOs) enter cells via scavenger receptors and EPHA2-mediated trafficking to reach nuclear-adjacent endosomes, enhancing their effectiveness.