Cell BiologybioRxivPreprint
EPHA2 and scavenger receptor-directed trafficking enhances endosomal leakiness and antisense therapy delivery
Sergi Marco, Peter J. Walsh, Alexey S. Revenko…·Jim C. Norman
This study identifies a mechanism by which antisense oligonucleotides (ASOs) enter cells via scavenger receptors and EPHA2-mediated trafficking to reach nuclear-adjacent endosomes, enhancing their effectiveness.
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