ATF2 phosphorylation is a core transcriptional driver of neuron apoptosis
Jorge Gómez-Deza, Matthew Nebiyou, Lara H. El Touny, Mor R. Alkaslasi, Zhenyu Zuo, Josette J Wlaschin, Francisco Manuel Nadal-Nicolás, Alexandra Stavsky, Xiaotian Zhang, Anastasia L. Slavutsky, Ariel Y. Zhang, Eliza Y. H. Lloyd, Peter M. Hayashi, Nathan Ashby, Mariella G. Brueck, , Claire E. Le Pichon
The paper identifies ATF2 phosphorylation as a key driver of neuron apoptosis and shows that inhibiting ATF2 protects neurons in culture and in vivo.
Neuron · May 19, 2026Peer-reviewedNeuroscience