Claire E. Le Pichon

ATF2 phosphorylation is a core transcriptional driver of neuron apoptosis

The paper identifies ATF2 phosphorylation as a key driver of neuron apoptosis and shows that inhibiting ATF2 protects neurons in culture and in vivo.

Statins and genetic inhibition of the mevalonate pathway activate an ATF3-STMN2 regenerative program

The paper shows statins and mevalonate pathway inhibition increase STMN2 and ATF3, promoting neuronal regeneration in neurodegenerative disease.

The transcriptional response of cortical neurons to concussion reveals divergent fates after injury

This study examines how cortical neurons respond to mild TBI, identifying ATF3 as a marker for stress-responsive neurons and showing that layer V neurons die while layer II/III neurons survive.

DLK-dependent axonal mitochondrial fission drives degeneration following axotomy

This study develops a human iPSC model of axonal degeneration, identifies DLK-dependent mitochondrial fission as a key mechanism, and shows CRISPR-mediated Drp1 depletion protects neurons from degeneration.

Creation of de novo cryptic splicing for ALS/FTD precision medicine

The paper develops TDP-REG, a system using cryptic splicing to enable precise gene therapy activation in diseased neurons for ALS/FTD.

Local production of reactive oxygen species drives vincristine-induced axon degeneration

This study identifies a mechanism by which vincristine induces axon degeneration through increased reactive oxygen species production in axons and shows potential therapeutic interventions.

A Cellular Taxonomy of the Adult Human Spinal Cord

This paper presents a cellular taxonomy of the adult human spinal cord using single nucleus RNA-sequencing and spatial transcriptomics, identifying 29 glial and 35 neuronal clusters and highlighting motoneuron vulnerability to ALS.

Medullary kappa-opioid receptor neurons inhibit pain and itch through a descending circuit

The paper identifies RVM neurons expressing the kappa-opioid receptor that inhibit pain and itch via a descending circuit in mice.

Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord

The paper uses single nucleus RNA sequencing to identify diverse cholinergic neuron types in the adult mouse spinal cord, revealing distinct transcriptomic classes of visceral and skeletal motor neurons.

Ventral arkypallidal neurons modulate accumbal firing to promote reward consumption.

This study identifies a specific subpopulation of ventral pallidal neurons that modulate nucleus accumbens firing to enhance reward consumption.