Targeted delivery of a phosphoinositide 3-kinase γ inhibitor to restore organ function in sepsis through dye-functionalized lipid nanocarriers
Adrian Tibor Press, Petra Babic, Bianca Hoffmann, Tina Müller, Wanling Foo, Walter Hauswald, Jovana Benecke, Martina Beretta, Zoltán Cseresnyés, Stephanie Hoeppener, Ivo Nischang, Sina Maren Coldewey, Markus H. Gräler, Reinhard Bauer, Falk A. Gonnert, , Michael W Bauer
The paper demonstrates that dye-functionalized lipid nanocarriers can deliver a PI3Kγ inhibitor to hepatocytes, restoring liver function in sepsis without affecting immune responses.
bioRxiv · Jan 20, 2021 · PreprintMolecular Biology