This study investigates sex-dependent proteomic changes in young and aged mouse peripheral nerves during ex vivo degeneration, revealing sex-specific molecular features of nerve ageing.

bioRxiv · Aug 10, 2026 · PreprintNeuroscience

A Multicenter Confirmatory Randomized-Controlled Study of rhNRGβ1 Protein Replacement Therapy in a Murine Model of NF2-related Schwannomatosis

Michael Reuter, Susann Groth, Johanna Schleep, Lars Björn Riecken, Lisa Schindler, Marie Juliane Jung, Venkat Krishnan Sundaram, Emilio Cirri, Nadine Pömpner, Lisa Wedekind, Julia Palm, André Scherag, Ruth Martha Stassart, Robert Fledrich, Reinhard Bauer, Helen Morrison

Across three German sites and 207 analyzed mice, systemic rhNRGβ1 at 10 µg/kg did not reduce schwannoma nerve thickness or shift Schwann cell differentiation markers.

bioRxiv · Aug 4, 2026 · PreprintCancer Biology✦ In-depth digest

Distinct Effects of Aging and Klotho Deletion on the Choroid Plexus

Zahra Fanaei‐Kahrani, Tushar Patel, Christina Valkova, Alexander Gloria, Justine Wagner, Heike Heuer, Markus Schwaninger, Steve Hoffmann, Reinhard Bauer, Christoph Kaether

This study examines how aging and Klotho deletion affect choroid plexus structure and function, finding that Klotho deficiency increases age-related calcification in specific regions.

GeroScience · Mar 25, 2026Peer-reviewedNeuroscience

Convergent molecular signatures of ageing and injury in the peripheral nervous system

Dario Lucas Helbing, Michael Reuter, Emilio Cirri, Therese Dau, Joanna M Kirkpatrick, Amy Stockdale, Alexander Schulz, Nova Oraha, Leopold Böhm, Philipp Koch, Leonie Karoline Stabenow, Alexander Weuthen, Nadja Gebert, Martin Walter, Alessandro Ori‬‬, , Helen Morrison

This study compares molecular changes in PNS ageing, dietary restriction, and injury, finding similar proteomic signatures between ageing and injury.

bioRxiv · Feb 11, 2026 · PreprintNeuroscience

Impact of inflammatory preconditioning on murine microglial proteome response induced by focal ischemic brain injury

Dario Lucas Helbing, Fabienne Haas, Emilio Cirri, Norman Rahnis, Therese Dau, Erika Kelmer Sacramento, Nova Oraha, Leopold Böhm, Trim Lajqi, Pascal Fehringer, Helen Morrison, Reinhard Bauer

The paper investigates how LPS preconditioning affects microglial proteome response to focal ischemic brain injury in mice, finding significant neuroprotection and changes in proteome patterns linked to type I interferons.

Frontiers in Immunology · Apr 9, 2024Peer-reviewedNeuroscience

Proteomic analysis of peripheral nerve myelin during murine aging

Dario Lucas Helbing, Joanna M Kirkpatrick, Michael Reuter, Julia Bischoff, Amy Stockdale, Annemarie Carlstedt, Emilio Cirri, Reinhard Bauer, Helen Morrison

This study investigates changes in the myelin proteome of mouse peripheral nerves during aging, finding only subtle changes and proposing the dataset as a resource for future research.

Frontiers in Cellular Neuroscience · Oct 30, 2023Peer-reviewedNeuroscience

Targeted delivery of a phosphoinositide 3-kinase γ inhibitor to restore organ function in sepsis through dye-functionalized lipid nanocarriers

Adrian Tibor Press, Petra Babic, Bianca Hoffmann, Tina Müller, Wanling Foo, Walter Hauswald, Jovana Benecke, Martina Beretta, Zoltán Cseresnyés, Stephanie Hoeppener, Ivo Nischang, Sina Maren Coldewey, Markus H. Gräler, Reinhard Bauer, Falk A. Gonnert, , Michael W Bauer

The paper demonstrates that dye-functionalized lipid nanocarriers can deliver a PI3Kγ inhibitor to hepatocytes, restoring liver function in sepsis without affecting immune responses.

bioRxiv · Jan 20, 2021 · PreprintMolecular Biology