The paper identifies sepsis subtypes in blood and liver and shows that CXCR2 blockade improves survival only in specific subtypes, highlighting the need for precision therapy.

bioRxiv · Aug 4, 2026 · PreprintSystems Biology

LILRA5 functions to induce ROS production on innate immune cells

Zuyi Fu, Matevž Rumpret, Irina Kube‐Golovin, Mykola Lyndіn, Vera Solntceva, Yuxi Zhao, А. А. Кониева, Na Liu, Adrian Tibor Press, Stefanie B. Flohé, Michael W Bauer, Gunther Wennemuth, Bernhard B. Singer, Alex J. McCarthy

This study identifies LILRA5 as an activating receptor on phagocytes that stimulates ROS production and shows its dynamic regulation in response to infection and inflammation.

bioRxiv · Mar 16, 2025 · PreprintImmunology

Targeted delivery of a phosphoinositide 3-kinase γ inhibitor to restore organ function in sepsis through dye-functionalized lipid nanocarriers

Adrian Tibor Press, Petra Babic, Bianca Hoffmann, Tina Müller, Wanling Foo, Walter Hauswald, Jovana Benecke, Martina Beretta, Zoltán Cseresnyés, Stephanie Hoeppener, Ivo Nischang, Sina Maren Coldewey, Markus H. Gräler, Reinhard Bauer, Falk A. Gonnert, , Michael W Bauer

The paper demonstrates that dye-functionalized lipid nanocarriers can deliver a PI3Kγ inhibitor to hepatocytes, restoring liver function in sepsis without affecting immune responses.

bioRxiv · Jan 20, 2021 · PreprintMolecular Biology