Cell-of-Origin, not Oncogenic Effect, Determines esmoplastic Immune Exclusion in KRAS-Driven Liver Cancer
Chunshan Liu, Yule Wu, Daria Komkova, Viktorie Gabrielová, Zeynep ÇİL, Trinh Kieu Dinh, Maximilian Zehender, Martin Schneider, Nugzar Lekiashvili, Philip Puchas, Darjus Felix Tschaharganeh, Mathias F Heikenwälder, Silvia Affò, Christoph Springfeld, Jan Pfeiffenberger, , Michael T. Dill
This study shows that the cell-of-origin, not oncogenic pathway activation, determines the desmoplastic immune-excluded tumor microenvironment in KRAS-driven liver cancer.
bioRxiv · Mar 26, 2026 · PreprintCancer Biology