Mathias F Heikenwälder

Preclinical antiviral study of a liver-targeted TLR1/2 agonist in an immune-competent mouse model of HBV infection

This study evaluates a liver-targeted TLR1/2 agonist nanoparticle formulation for HBV treatment, showing enhanced antiviral effects compared to free agonist in mice.

Cell-of-Origin, not Oncogenic Effect, Determines esmoplastic Immune Exclusion in KRAS-Driven Liver Cancer

This study shows that the cell-of-origin, not oncogenic pathway activation, determines the desmoplastic immune-excluded tumor microenvironment in KRAS-driven liver cancer.

Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis.

This study identifies plectin as a critical mediator of mechanical homeostasis in hepatocellular carcinoma, showing that its inhibition suppresses tumor growth and metastasis.

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumourigenesis

The paper identifies PROX1 as a safeguard repressor that maintains hepatocyte identity and prevents liver tumourigenesis by repressing alternate fate regulators.

Sustained innate interferon is an essential inducer of tertiary lymphoid structures

This study identifies sustained type I interferon signaling as essential for the development of functional tertiary lymphoid structures in the lungs during inflammation.

Single-cell and spatial atlas of steatotic liver-related hepatocellular carcinoma

This study characterizes the tumor microenvironment of steatotic liver-related hepatocellular carcinoma using single-cell and spatial transcriptomic analyses, identifying immunosuppressive features and Treg-CAF interactions linked to immunotherapy resistance.

Epithelial cells of the intestine acquire cell-intrinsic inflammation signatures during ageing

This study shows that aged intestinal epithelial cells exhibit a persistent inflammation signature, marked by MHC class II upregulation and increased chromatin accessibility of inflammation-associated loci.

Spatial single-cell profiling of intracellular metabolomes in situ

SpaceM integrates MALDI-imaging mass spectrometry with pre- and post-MALDI microscopy to measure >100 metabolites in >10000 individual cultured cells alongside fluorescence, morphology and spatial context.