Darjus Felix Tschaharganeh

This study shows that the cell-of-origin, not oncogenic pathway activation, determines the desmoplastic immune-excluded tumor microenvironment in KRAS-driven liver cancer.

This study shows BAP1 regulates liver homeostasis and tumor suppression by modulating ER stress and DDIT3 expression in response to metabolic stress.

The paper identifies MPZL1 as a therapeutic target in 1q-amplified solid cancers by repurposing passenger amplifications as Trojan horses for targeted therapy delivery.

The paper introduces CHOCOLAT-G2P, a method integrating functional genomics and spatial transcriptomics to study genotype-phenotype relationships in tumors, revealing zonation patterns and epistasis in liver cancer.

The paper identifies PROX1 as a safeguard repressor that maintains hepatocyte identity and prevents liver tumourigenesis by repressing alternate fate regulators.