Cellular senescence dysregulates antiviral interferon responses in idiopathic pulmonary fibrosis
Jun‐Wei B. Hughes, Yasmina Reisser, Franziska Hornung, Tyler A. U. Hilsabeck, Fiona Senchyna, A L Coelho, Tsung Che Ho, Kevin Schneider, David Furman, Cory M. Hogaboam, Claude Jourdan Le Saux, Pierre-Yves Desprez, Stefanie Deinhardt‐Emmer
This study shows that cellular senescence in IPF fibroblasts disrupts antiviral responses, leading to increased viral titers and altered inflammation.
bioRxiv · Apr 23, 2026 · PreprintCell Biology