Lymph node contraction links sex-biased naive CD8 T cell decline to compromised antigen recognition during middle age
Lutz Menzel, Maria Zschummel, Meghan J. O’Melia, Mårten Sandstedt, Hengbo Zhou, Pin-Ji Lei, Lingshan Liu, Hang Lee, Debattama R. Sen, Lance L. Munn, Lena Jonasson, Timothy P. Padera
This study identifies sex-biased mechanisms of immune aging in males, showing lymph node contraction reduces naive CD8 T cell availability and compromises cancer antigen recognition, with potential therapeutic interventions.
Nature Aging · Oct 9, 2026Peer-reviewedImmunology