Author

Hengbo Zhou

Harvard UniversityORCID 0000-0002-9948-7909Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Lance L. MunniD· 2 shared Lingshan LiuiD· 2 shared Lutz MenzeliD· 2 shared Meghan J. O’MeliaiD· 2 shared Timothy P. PaderaiD· 2 shared Debattama R. SeniD· 1 shared Genevieve Marie BolandiD· 1 shared Hang LeeiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Lance L. MunnORCID

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2 papers

Recent·Most cited

Lymph node contraction links sex-biased naive CD8 T cell decline to compromised antigen recognition during middle age

Lutz Menzel, Maria Zschummel, Meghan J. O’Melia, Mårten Sandstedt, Hengbo Zhou, Pin-Ji Lei, Lingshan Liu, Hang Lee, Debattama R. Sen, Lance L. Munn, Lena Jonasson, Timothy P. Padera

This study identifies sex-biased mechanisms of immune aging in males, showing lymph node contraction reduces naive CD8 T cell availability and compromises cancer antigen recognition, with potential therapeutic interventions.

Nature Aging · Oct 9, 2026Peer-reviewedImmunology

Overcoming impaired antigen presentation in tumor draining lymph nodes facilitates immunotherapy

Meghan J. O’Melia, Lutz Menzel, Pin‐Ji Lei, Hengbo Zhou, Xingjian Zhang, Neian Contreras-Alvarado, Johanna J. Rajotte, Lingshan Liu, Mohammad R. Nikmaneshi, James W. Baish, Jessalyn M. Ubellacker, Genevieve Marie Boland, Sonia Cohen, Timothy P. Padera, Lance L. Munn

This study shows that breast tumors impair antigen presentation in local lymph nodes, which can be overcome by delivering IL1β or adjuvants to distant lymph nodes, improving anti-cancer immune responses.

Journal for ImmunoTherapy of Cancer · Dec 1, 2025Peer-reviewedCancer Biology