Identification and functional characterization of an AMD associated c-ABL binding SNP streak within the ARMS2 gene promoter region
Ping-Wu Zhang, Sheng Liu, Weifeng Li, Laura Fan, Sean Li, Zi-He Wan, Cynthia A. Berlinicke, Shannath L. Merbs, Donald J. Zack
The paper identifies a 5-SNP block in the ARMS2 promoter that binds c-ABL and is associated with AMD, showing reduced transcriptional activity in reporter assays.
bioRxiv · Oct 27, 2025 · PreprintMolecular Biology