Xitiz Chamling

This study shows that inflammation disrupts oligodendrocyte precursor cell lipid metabolism, impairing remyelination, and that activating liver X receptors can restore lipid balance and promote myelin repair.

The paper identifies stage-specific miRNAs involved in human oligodendrocyte precursor cell differentiation and maturation through miRNA profiling of hESC-derived cells.

The paper shows that indole lactate (ILA), reduced in MS, restores gut microbiome metabolic balance, promoting remyelination and reducing neuroinflammation.

The paper identifies novel pathways that enhance oligodendrocyte maturation and myelination through high-throughput screening of 2500 compounds using engineered human stem cell-derived OPCs.

The paper uses single-cell transcriptomics to analyze human oligodendrocyte progenitor cells, revealing transcriptional heterogeneity and pathways involved in their differentiation.

The paper shows thyroid hormone signaling controls the temporal switch between S and L/M cone fates in human retinal organoids.

The paper characterizes the transcriptome of human stem cell-derived retinal ganglion cells using single-cell RNA sequencing, identifying three subpopulations with varying maturity levels.

This paper develops an automated system for maintaining and differentiating human pluripotent stem cells, enabling large-scale culture and reducing variability.