Samer S Hattar

Parallel circadian-like oscillations in LTP and excitation inhibition balance in mouse CA1 reverse direction after puberty

The paper shows that LTP and E/I ratio oscillate with the light-dark cycle in mouse CA1, reversing direction after puberty.

Pde10a gates light responses in the SCN to regulate circadian photoentrainment

The paper identifies Pde10a as a key regulator of SCN light responsiveness during the day, maintaining circadian photoentrainment in mice.

Light modulates glucose and lipid homeostasis via the sympathetic nervous system

This study shows that light affects glucose and lipid metabolism in mice through the sympathetic nervous system, independent of circadian rhythms, and that these effects can be reversed with light exposure.

A conserved cell-type gradient across the human mediodorsal and paraventricular thalamus

The paper identifies a conserved excitatory neuron gradient in human mediodorsal thalamus using single-nucleus and spatial transcriptomics, linking it to psychiatric disorder risk.

Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells

The paper constructs an intercellular communication atlas of the retina, identifying Oprm1 as a neuroprotective factor that enhances RGC survival through ligand-receptor interactions.

Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice

This study shows that sympathetic NPY is critical for metabolic and cardiovascular regulation in mice, affecting glucose homeostasis, cold tolerance, and heart rate.

Satellite glia are essential modulators of sympathetic neuron survival, activity, and autonomic function

This study shows satellite glia are essential for sympathetic neuron survival, activity, and autonomic function in mice, with implications for cardiovascular disease and hypertension.

Diversity of satellite glia in sympathetic and sensory ganglia

This study identifies five distinct satellite glia populations in sympathetic and sensory ganglia using single-cell RNA sequencing, revealing functional diversity and unique transcriptional signatures.

Atoh7-independent specification of retinal ganglion cell identity

This study shows that Atoh7 is essential for RGC survival but not for their specification, as RGCs can develop without Atoh7 when apoptosis is inhibited.

The projections of ipRGCs and conventional RGCs to retinorecipient brain nuclei

This study shows conventional RGCs innervate ipRGC-recipient nuclei beyond the suprachiasmatic nucleus, revealing distinct stratification patterns and innervation differences.

Retinal circuits driving a non-image forming visual behavior

This study identifies the retinal circuits responsible for the pupillary light response (PLR) in mice, showing that rods, not cones, drive the PLR across light intensities.

Distinct ipRGC subpopulations mediate light’s acute and circadian effects on body temperature and sleep

The paper shows that a specific subpopulation of ipRGCs projecting to the SCN mediates light's acute effects on body temperature and sleep, while other ipRGCs are involved in circadian regulation.

Thyroid hormone signaling specifies cone subtypes in human retinal organoids

The paper shows thyroid hormone signaling controls the temporal switch between S and L/M cone fates in human retinal organoids.