Shane M. Harding

PENNE infers whole-transcriptomic profiles from live-cell images using domain adaptation, capturing temporal gene dynamics and cell-type markers.

This study shows that BRCA1 mutations impair the G1/S checkpoint in luminal progenitors, altering their response to irradiation stress compared to basal cells.

This paper introduces a machine learning tool for micronuclei segmentation and refines nuclei-micronuclei relationships using a two-phase labeling approach and a Mask-RCNN model.

This study identifies DNA-PK as a synthetic lethal target in TP53-deficient SHH medulloblastoma, showing that inhibiting DNA-PK enhances radiosensitivity and improves survival in preclinical models.

The paper shows that dU-rich cytoplasmic DNA inhibits STING-dependent immune responses and enhances anti-PD-L1 therapy efficacy in tumors.