De Novo Hepatic Pyrimidine Synthesis Regulates Systemic Energy Homeostasis
Ling Fu, Pradnya H. Patil, Pengfei Zhang, Ignacio Norambuena‐Soto, Qiutang Xiong, Yin Wang, Chelsea Jang, Kevin Wang, Yunqian Peng, Lu Ding, Patrick T. Fueger, Lihua Jin, Wendong Huang, Philip L. Lorenzi, Lin Tan, , Yingfeng Deng
This study shows that reduced hepatic pyrimidine synthesis during fasting and obesity promotes insulin resistance and obesity by increasing hepatic glucose production and decreasing insulin clearance.
bioRxiv · Nov 18, 2025 · PreprintPathology