Yingfeng Deng

This study investigates the role of UPP1 in β-cell function and shows that UPP1 deficiency impairs uridine-potentiated GSIS and MAPK activation in mice and humans.

This study shows that reduced hepatic pyrimidine synthesis during fasting and obesity promotes insulin resistance and obesity by increasing hepatic glucose production and decreasing insulin clearance.

This study uses multi-omic profiling to show that senescent cells, particularly late myofibroblasts, transiently contribute to cardiac remodeling after myocardial infarction.