Author

Chelsea Jang

City Of Hope National Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Ignacio Norambuena‐SotoiD· 2 shared Kevin Wang· 2 shared Ling FuiD· 2 shared Philipp E. SchereriD· 2 shared Qiutang Xiong· 2 shared Yingfeng DengiD· 2 shared YUNQIAN PENG· 2 shared Zhao V. WangiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Ignacio Norambuena‐SotoORCID

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2 papers

Recent·Most cited

Role of Uridine Phosphorylase 1 (UPP1) in Pancreatic β-Cell Physiology and Its Dysregulation in Obesity and Type 2 Diabetes

YUNQIAN PENG, Lu Ding, Qiutang Xiong, Ling Fu, Chelsea Jang, Yin Wang, Ignacio Norambuena‐Soto, Kevin Wang, Gemin Lu, Erika M. McCown, Eunjin Oh, Lin Tan, Jeffrey Scott Isenberg, Ping Wang, Philipp E. Scherer, , Yingfeng Deng

This study investigates the role of UPP1 in β-cell function and shows that UPP1 deficiency impairs uridine-potentiated GSIS and MAPK activation in mice and humans.

bioRxiv · Sep 28, 2026 · PreprintMolecular Biology

De Novo Hepatic Pyrimidine Synthesis Regulates Systemic Energy Homeostasis

Ling Fu, Pradnya H. Patil, Pengfei Zhang, Ignacio Norambuena‐Soto, Qiutang Xiong, Yin Wang, Chelsea Jang, Kevin Wang, Yunqian Peng, Lu Ding, Patrick T. Fueger, Lihua Jin, Wendong Huang, Philip L. Lorenzi, Lin Tan, , Yingfeng Deng

This study shows that reduced hepatic pyrimidine synthesis during fasting and obesity promotes insulin resistance and obesity by increasing hepatic glucose production and decreasing insulin clearance.

bioRxiv · Nov 18, 2025 · PreprintPathology