Author

Ignacio Norambuena‐Soto

City Of Hope National Medical CenterORCID 0000-0002-2676-2674Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Chelsea Jang· 2 shared Kevin Wang· 2 shared Ling FuiD· 2 shared Philipp E. SchereriD· 2 shared Qiutang Xiong· 2 shared Yingfeng DengiD· 2 shared YUNQIAN PENG· 2 shared Zhao V. WangiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Chelsea Jang

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 28, 2026

Role of Uridine Phosphorylase 1 (UPP1) in Pancreatic β-Cell Physiology and Its Dysregulation in Obesity and Type 2 Diabetes

YUNQIAN PENG, Lu Ding, Qiutang Xiong…·Yingfeng Deng

This study investigates the role of UPP1 in β-cell function and shows that UPP1 deficiency impairs uridine-potentiated GSIS and MAPK activation in mice and humans.

DOI 10.64898/2026.09.24.754194

mousehuman

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PathologybioRxivPreprintNov 18, 2025

De Novo Hepatic Pyrimidine Synthesis Regulates Systemic Energy Homeostasis

Ling Fu, Pradnya H. Patil, Pengfei Zhang…·Yingfeng Deng

This study shows that reduced hepatic pyrimidine synthesis during fasting and obesity promotes insulin resistance and obesity by increasing hepatic glucose production and decreasing insulin clearance.

1 citation

mouseexperimental assay

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