PathologybioRxivPreprint
De Novo Hepatic Pyrimidine Synthesis Regulates Systemic Energy Homeostasis
Ling Fu, Pradnya H. Patil, Pengfei Zhang…·Yingfeng Deng
This study shows that reduced hepatic pyrimidine synthesis during fasting and obesity promotes insulin resistance and obesity by increasing hepatic glucose production and decreasing insulin clearance.
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