HIV Diversity Considerations in the Application of the Intact Proviral DNA Assay (IPDA)
Natalie N. Kinloch, Yanqin Ren, Winiffer D. Conce Alberto, Winnie W. Y. Dong, Pragya Khadka, Szu-Han Huang, Talia M. Mota, Andrew Wilson, Aniqa Shahid, Don Kirkby, Marianne Harris, Colin M Kovacs, Erika Benko, Mario Ostrowski, Perla M. Del Río Estrada, , Richard Brad Jones
The paper evaluates the Intact Proviral DNA Assay (IPDA) for HIV reservoir quantification, finding that HIV diversity leads to a 28% failure rate and underestimation of reservoir size.
Nature Communications · Jan 8, 2021Peer-reviewedGenetics