Andrew Wilson

Functional Characterization of Myeloid Neoplasm-associated DDX41 Variants Reveals Pathogenic Interaction with Acquired Hotspot Mutation

The paper functionally characterizes DDX41 variants, showing some non-truncating germline variants are susceptible to dominant-negative effects by the somatic hotspot mutation p.R525H.

The proteomic landscape of proteotoxic stress in a fibrogenic liver disease

This study uses spatial proteomics and machine learning to analyze AATD in human liver tissue, revealing peroxisomal upregulation and a terminal hepatocyte state with distinct proteomic signatures.

Reinforced CRISPR interference enables reliable multiplex gene repression in phylogenetically distant bacteria

This paper develops a CRISPRi platform for multiplex gene repression in diverse bacteria, demonstrating its effectiveness in multiple species.

Neurons in the dorsomedial hypothalamus promote, prolong, and deepen torpor

This study identifies DMH neurons active during torpor in mice and shows they promote and prolong torpor, but are not sufficient for its initiation.

HIV Diversity Considerations in the Application of the Intact Proviral DNA Assay (IPDA)

The paper evaluates the Intact Proviral DNA Assay (IPDA) for HIV reservoir quantification, finding that HIV diversity leads to a 28% failure rate and underestimation of reservoir size.