Minimal Perturbation of Activation Loop Dynamics Rewires KinaseSignaling
Prashant Jain, Dariia Yehorova, Ririn Rahmala Febri, Ben E. Clifton, Andrey O. Demkiv, Gen‐ichiro Uechi, Michael Robinson, Shina Caroline Lynn Kamerlin, Mariko Okada, Akira Imamoto, Paola Laurino
The paper identifies a triple-deletion mutant of SRC kinase that alters activation loop dynamics, leading to changes in substrate preference and signaling outcomes.
bioRxiv · Oct 15, 2025 · PreprintBiochemistry