Author

Dariia Yehorova

Georgia Institute of TechnologyORCID 0000-0002-4091-4945Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Shina Caroline Lynn KamerliniD· 3 shared Michael RobinsoniD· 2 shared Akira ImamotoiD· 1 shared Alvan C. HenggeiD· 1 shared Andrey O. DemkiviD· 1 shared Ben E. CliftoniD· 1 shared Chitra RajendraniD· 1 shared Dinesh Ravindra RajuiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

Shina Caroline Lynn KamerlinORCID

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3 papers

Recent·Most cited

Conformational Dynamics and Catalytic Backups in a Hyper-Thermostable Engineered Archaeal Protein Tyrosine Phosphatase

Dariia Yehorova, Nikolas Alansson, Ruidan Shen, Joshua Denson, Michael Robinson, Valeria A. Risso, Nuria Ramirez Molina, J. Patrick Loria, Eric A. Gaucher, José M. Sánchez‐Ruiz, Alvan C. Hengge, Sean J. Johnson, Shina Caroline Lynn Kamerlin

This paper describes an engineered archaeal PTP with enhanced thermostability and unique biochemical properties, revealing insights into enzyme evolution and biotechnological potential.

JACS Au · Dec 10, 2025Peer-reviewedBiochemistry

Minimal Perturbation of Activation Loop Dynamics Rewires KinaseSignaling

Prashant Jain, Dariia Yehorova, Ririn Rahmala Febri, Ben E. Clifton, Andrey O. Demkiv, Gen‐ichiro Uechi, Michael Robinson, Shina Caroline Lynn Kamerlin, Mariko Okada, Akira Imamoto, Paola Laurino

The paper identifies a triple-deletion mutant of SRC kinase that alters activation loop dynamics, leading to changes in substrate preference and signaling outcomes.

bioRxiv · Oct 15, 2025 · PreprintBiochemistry

Conformational modulation of a mobile loop controls catalysis in the (βα)8-barrel enzyme of histidine biosynthesis HisF

Enrico Hupfeld, Sandra Schlee, Jan Philip Wurm, Chitra Rajendran, Dariia Yehorova, Eva Vos, Dinesh Ravindra Raju, Shina Caroline Lynn Kamerlin, Remco Sprangers, Reinhard Sterner

This study investigates how conformational changes in a mobile loop of the HisF enzyme regulate catalytic steps in histidine biosynthesis.

JACS Au · Aug 15, 2024Peer-reviewedBiochemistry