Q. Shi

This study identifies Notopterol as a JAK2/3 inhibitor that reduces inflammation and arthritis by blocking macrophage cytokine production in animal models.

This study identifies two benzophenanthridine alkaloids from Corydalis longicalcarata rhizomes with anti-mitotic and polyploidy-inducing activities through a phenotypic screen of medicinal plant extracts.

This paper identifies dimethylfasudil as a synthetic lethal compound for MYC-overexpressing cells through a high-content screen, showing its efficacy in rodent and human cell lines.

This paper uses single-cell RNA sequencing to characterize neutrophil heterogeneity and maturation during homeostasis and bacterial infection, revealing distinct subsets and their functional transitions.

The paper shows Bcl-2 and Bcl-xL reduce autophagic cell death in polyploid cells treated with Aurora-B kinase inhibitors, contributing to resistance to these drugs.

This study shows β-blockers like carvedilol can activate β2AR at low concentrations, enhancing L-type Ca2+ channel activity in neurons through localized cAMP/PKA signaling.

This study identifies molecular mechanisms of shade responses in maize by analyzing transcriptome changes and functionally testing a key transcription factor.

This study shows that small intestinal lactobacilli can resist the toxicity of soybean oil fatty acids through environmental protection and evolutionary adaptation.

This paper introduces ArrayG, a fluorogenic system for long-term single molecule tracking, and demonstrates its application in studying molecular dynamics in living cells.