Microbiome depletion rejuvenates the aging brain
Caterina Gasperini, Kristina M. Holton, Francesco Limone, Mahitha Juttu, Cristina C. DeMeo, Kristina Kekrtova, Sayalee Patankar, Kaylee M Wells, Richard M. Giadone, Laura Ben Driss, Guoqin Wei, Anna Kiem, Qiaohan Xu, Richard Lee, Martin Friedlander, , Lee L. Rubin
The paper shows that depleting the gut microbiome in aged mice rejuvenates the brain by improving vascular density, myelination, neurogenesis, and reducing inflammation.
bioRxiv · Feb 15, 2026 · PreprintNeuroscience